Most recent Editor's Choice
Background Managing drug–food interactions may help to achieve the optimal action and safety profile of β-lactam antibiotics. Methods We conducted a systematic review with meta-analyses in adherence to PRISMA guidelines for 32 β-lactams. We included 166 studies assessing the impact of food, ...
Latest Published Articles
Objectives Posaconazole is increasingly used for the treatment and prophylaxis of invasive fungal infections in immunocompromised children. We aimed to review evidence for paediatric posaconazole dosing regimens focusing on attainment of target concentrations and frequency of adverse effects. ...
Norepinephrine (NE), a host-derived stress-related hormone, is released from the sympathetic nervous system during acute threats, leading to increased serum levels. 1 Previous studies have identified NE as a new inter-kingdom signalling molecule, enhancing growth, pathogenicity and biofilm ...
Objectives To characterize and elucidate the spread of amikacin-resistant Enterobacteriaceae isolates from environmental samples on a pig farm in the UK, following the previous identification of index Salmonella isolates harbouring the rmtB gene, a 16S rRNA methylase. Methods Environmental samples ...
Lenacapavir is a very recent first-in-class capsid inhibitor approved for HIV-1 treatment. 1 It is a long-acting antiretroviral intended for dosing twice a year by subcutaneous injection. In combination with other antiretrovirals, lenacapavir is indicated in heavily treatment-experienced adults ...
Background Antibiotic exposure increases antimicrobial resistance and has also been associated with long-term harms, including allergies, inflammatory diseases and weight gain. We assessed antibiotic exposure in the first 2 years of life in Australian children, the factors influencing this and its ...
Systemic antifungal therapy is critical for reducing the mortality from many invasive and chronic fungal infections. Triazole antifungals are the most frequently prescribed antifungals but require attention to dosing and drug interactions. Nearly 600 severe drug–drug interactions and over 1100 ...
Background Aminoglycosides (AGs) are important antibiotics in the treatment of Gram-negative sepsis. However, they are associated with the risk of irreversible sensorineural hearing loss (SNHL). Several genetic variants have been implicated in the development of ototoxicity. Objectives To evaluate ...
Background Riemerella anatipestifer encodes an iron acquisition system, but whether it encodes the iron efflux pump and its role in antibiotic resistance are largely unknown. Objectives To screen and identify an iron efflux gene in R. anatipestifer and determine whether and how the iron efflux gene ...
Candidatus Accumulibacter is a genus belonging to Betaproteobacteria with no validated species on the the List of Prokaryotic Names with Standing in Nomenclature (LPSN) website ( https://lpsn.dsmz.de/genus/accumulibacter ). The Candidatus Accumulibacter genus is composed of Gram-negative bacilli ...
Background IV fosfomycin is used against MDR Gram-negative bacilli (GNB) but has dose-limiting side effects, especially in patients with impaired kidney function. Objectives To determine the optimal dosage of IV fosfomycin for patients with varying degrees of kidney function. Methods Adult patients ...
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- Future challenges in the management of serious infections
- Syndromic diagnostics: better timing and better insights to deliver improvement to patient experience and outcomes
- European surveillance of antimicrobial consumption: antibiotic consumption in the community, 1997–2017
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